黄漫娜 [副教授]
基本情况
博士，副教授，博士生导师
联系方式
通讯地址：广东省珠海市唐家湾中山大学化学工程与技术学院
邮编：519082
教育经历
2006年9月—2010年7月，中山大学，学士学位；
2010年9月—2015年7月，中山大学，博士学位，导师：万一千教授；
2012年11月—2013年10月，美国北卡罗来纳大学教堂山分校医学院，访问学者，合作导师：柯衡明教授。
工作经历
2018年08月 - 至今 中山大学，化学工程与技术学院，副教授
2016年03月 – 2018年07月 中山大学，化学工程与技术学院，副研究员
2015年07月 – 2016年03月 中山大学，化学与化学工程学院，副研究员
讲授课程
有机化学实验，化工原理实验
科研方向
功能有机分子的设计与绿色合成；有机药物化学与制药工程
科研项目
01. 新型抗耐药菌药物-NDM1抑制剂的研究（中山大学青年教师培育项目，主持）
02. 抗新型耐药菌的药物设计、合成与活性研究（广州市科技计划项目，主持）
03. 基于天然多酮类化合物结构改造的NDM-1抑制剂的设计、合成和构效研究（国家自然科学基金青年项目，主持）
论著一览
01. Manna Huang; Jie Zhou; Ke Xu; Xinhai Zhu; Yiqian Wan, Enhancement of the excited-state intramolecular proton transfer process to produce all-powerful DSE molecules for bridging the gap between ACQ and AIE. Dyes and Pigments 2019, 160, 839-847.
02. P. Zhang; S. Li; S. Zhang; X. Zhang; L. Wan; Z. Yun; S. Ji; F. Gong; M. Huang; L. Wang; X. Zhu; Y. Tan; Y. Wan, GRGDS-functionalized chitosan nanoparticles as a potential intravenous hemostat for traumatic hemorrhage control in an animal model. Nanomedicine 2018.
03. Zhou Yi; Manna Huang; Yiqian Wan; Xinhai Zhu, An Effective Heterogeneous Copper Catalyst System for C-N Coupling and Its Application in the Preparation of 2-Methyl-4-methoxydiphenylamine (MMDPA). Synthesis 2018, Ahead of Print.
04. Jie Zhou; Xinhai Zhu; Manna Huang; Yiqian Wan, SeO2-Mediated One-Pot Synthesis of 3-Cyanofurans from 3-Oxo-3-arylpropanenitriles and Substituted Acetaldehydes. Eur. J. Org. Chem. 2017, 2017 (16), 2317-2321.
05. Manna Huang; Shuxian Ye; Ke Xu; Jie Zhou; Jun-Liang Liu; Xinhai Zhu; Yiqian Wan, Whole-rainbow-color Organic Solid Fluorophores from Subtle Modification of Thiazolo[5,4-b]thieno[3,2-e]pyridines (TTPs). J. Mater. Chem. C 2017, 5, 3456-3460.
06. Xiaomei Ding; Manna Huang; Zhou Yi; Dongchen Du; Xinhai Zhu; Yiqian Wan, Room-Temperature CuI-Catalyzed Amination of Aryl Iodides and Aryl Bromides. J. Org. Chem. 2017, 82 (10), 5416-5423.
07. Guoquan Sun; Shuya Ren; Xinhai Zhu; Manna Huang; Yiqian Wan, Direct Arylation of Pyrroles via Indirect Electroreductive C-H Functionalization Using Perylene Bisimide as an Electron-Transfer Mediator. Org. Lett. 2016, 18 (3), 544-547.
08. Manna Huang; Ruina Yu; Ke Xu; Shuxian Ye; Shi Kuang; Xinhai Zhu; Yiqian Wan, An Arch-bridge-type Fluorophore for Bridging the Gap Between Aggregation-caused Quenching (ACQ) and Aggregation-induced Emission (AIE). Chem. Sci. 2016, 7, 4485-4491.
09. Senchuan Song; Manna Huang; Wenjun Li; Xinhai Zhu; Yiqian Wan, Efficient synthesis of indoles from 2-alkynylaniline derivatives in water using a recyclable copper catalyst system. Tetrahedron 2015, 71 (3), 451-456.
10. Manna Huang; Yongxian Shao; Jianying Hou; Wenjun Cui; Beibei Liang; Yingchuan Huang; Zhe Li; Yinuo Wu; Xinhai Zhu; Peiqing Liu; Yiqian Wan; Hengming Ke; Hai-Bin Luo, Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol. Pharmacol. 2015, 88 (5), 836-845.
11. Manna Huang; Dongting Huang; Xinhai Zhu; Yiqian Wan, Copper-Catalyzed Domino Reactions for the Synthesis of Phenothiazines. Eur. J. Org. Chem. 2015, 2015 (22), 4835-4839.
12. Yuanyuan Tian; Wenjun Cui; Manna Huang; Howard Robinson; Yiqian Wan; Yousheng Wang; Hengming Ke, Dual specificity and novel structural folding of yeast phosphodiesterase-1 for hydrolysis of second messengers cyclic adenosine and guanosine 3',5'-monophosphate. Biochemistry 2014, 53 (30), 4938-4945.
13. Yong-xian Shao; Manna Huang; Wenjun Cui; Ling-Jun Feng; Yinuo Wu; Yinghong Cai; Zhe Li; Xinhai Zhu; Peiqing Liu; Yiqian Wan; Hengming Ke; Hai-Bin Luo, Discovery of a phosphodiesterase-9A inhibitor as a potential hypoglycemic agent. J. Med. Chem. 2014, 57, 10304-10313.
14. Na-Na Shang; Yong-Xian Shao; Ying-Hong Cai; Matthew Guan; Manna Huang; Wenjun Cui; Lin He; Yan-Jun Yu; Lei Huang; Zhe Li; Xian-Zhang Bu; Hengming Ke; Hai-Bin Luo, Discovery of 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one as a phosphodiesterase-5 inhibitor and its complex crystal structure. Biochem. Pharmacol. 2014, 89 (1), 86-98.
15. Manna Huang; Jianying Hou; Ruiqiao Yang; Liting Zhang; Xinhai Zhu; Yiqian Wan, A Catalyst System, Copper/N-Methoxy-1H-pyrrole-2-carboxamide, for the Synthesis of Phenothiazines in Poly(ethylene glycol). Synthesis 2014, 46 (24), 3356-3364.
16. Leilei Wang; Manna Huang; Xinhai Zhu; Yiqian Wan, Polyethylene glycol (PEG-200)-promoted sustainable one-pot three-component synthesis of 3-indole derivatives in water. Applied Catalysis A: General 2013, 454, 160-163.
17. F. Meng; J. Hou; Y. X. Shao; P. Y. Wu; M. Huang; X. Zhu; Y. Cai; Z. Li; J. Xu; P. Liu; H. B. Luo; Y. Wan; H. Ke, Structure-Based Discovery of Highly Selective Phosphodiesterase-9A Inhibitors and Implications for Inhibitor Design. J. Med. Chem. 2012, 55 (19), 8549-8558.
18. Manna Huang; Leilei Wang; Xinhai Zhu; Zuxing Mao; Daizhi Kuang; Yiqian Wan, Amination of Aryl Halides by Using an Environmentally Benign, Recyclable Copper Catalyst. Eur. J. Org. Chem. 2012, 2012 (26), 4897-4901.
19. Jianwei Xie; Jinying Tian; Li Su; Manna Huang; Xinhai Zhu; Fei Ye; Yiqian Wan, Pyrrolo[2,3-c]azepine derivatives: A new class of potent protein tyrosine phosphatase 1B inhibitors. Bioorg. Med. Chem. Lett. 2011, 21 (14), 4306-4309.
20. Manna Huang; Xiaoqin Lin; Xinhai Zhu; Weili Peng; Jianwei Xie; Yiqian Wan, A Highly Versatile Catalytic System for N-Arylation of Amines with Aryl Chlorides in Water. Eur. J. Org. Chem. 2011, (24), 4523-4527.
21. Jianwei Xie; Xinhai Zhu; Manna Huang; Fei Meng; Man Wang; Yiqian Wan, Sc(OTf)3, a highly efficient and renewable catalyst for Michael addition of indoles to nitroolefins in water. Synth. Commun. 2010, 40 (21), 3259-3267.
22. Jianwei Xie; Xinhai Zhu; Manna Huang; Fei Meng; Weiwei Chen; Yiqian Wan, Pyrrole-2-carbohydrazides as Ligands for Cu-Catalyzed Amination of Aryl Halides with Amines in Pure Water. Eur. J. Org. Chem. 2010, (17), 3219-3223.